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  Contents > Previous page > Article detail print Order
o Issue N# 3 - 2014 o

RHINOLOGY

Polypose nasosinusienne associée à un déficit en sous-classes d'Immunoglobuline G : place de la substi­tu­tion en immunoglobulines polyvalentes


Authors : Nhung Tran Khai Hoan, Karmochkine M, Laccourreye O, Bonfils P. (Paris)

Ref. : Rev Laryngol Otol Rhinol. 2014;135,3:151-155.

Article published in french
Downloadable PDF document french



Summary : Purpose: To study the effect of the introduction of a substi­t­u­t­ion by intravenous Immunoglobulins (Ig IV) at patients with immunoglobulins G (IgG) subclasses deficiency and nasal polyposis. Material and methods: Prospective study concer­ning five patients with IgG subclasses deficiency and nasal polyposis treated by Ig IV. Rhinologic, otologic and pulmonary symptoms, exacerbations of nasal polyposis, chronic otitis and asthma as well as the number of antibiotics and corticoids treat­ments were counted during the Ig IV substitution. Objectives: To study the association between IgIV substitution and the number of exacerbations of nasal polyposis, chronic otitis, asthma and the number of antibiotics and corticoids treatments in patients with IgG subclasses deficiency and nasal polyposis. Results: Five patients with a IgG subclass deficiency and nasal polyposis were substituted. The number of antibiotics and corticoids cures increased at one patient and remained stable at four others. The number of sinus, ear and lung infec­tions as well as the global rhinologic score of symptoms and the endoscopic stage of the nasal polyposis remained stable. In the absence of efficiency of the treatment, this one was interrupted at the end of 6 months for patients n° 1 and n° 3, 24 months for patient n° 4 and 42 months for patient n° 5. Conclusion: The current study failed to highlight clinical improvement in patients wih IgG subclasses deficiency and nasal polyposis treated by Ig IV. A previous study had not allowed to find a link between IgG subclasses deficiency and severity of nasal polyposis, what seems to be confirmed by the absence of improvement brought during the substitution of this deficit in the current study.

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