Issue N# 3 - 2006
Amphicrine adenoma of the middle ear: Three cases reports and a review of the literature
Authors : K. Aubry, J. P. Sauvage, S. Puyraud (Limoges)
Ref. : Rev Laryngol Otol Rhinol. 2006;127,3:145-149.
Article published in french
Downloadable PDF document french
Amphicrine adenoma is an extremely rare tumor of the middle ear. We report three cases obtained over a twenty year period. The aim of this study is to discuss our clinical cases and review the literature. Materials and methods: Three cases of middle ear amphicrine tumour were reviewed. Results: During a 10 year period (1986-2006) three cases of middle ear amphicrine tumour were treated at our unit (2 male, 1 female). The presenting complaint was hearing loss in all 3 cases. Amphicrine adenoma is diagnosed by an immuno-histological examination of pathological specimens. Differential diagnosis can be difficult and one individual was initially treated as an adenocarcinoma by radiotherapy. This patient succumbed to cerebral mycosis two years post-radiotherapy. The other two patients have no evidence of recurrence eight and nine years post treatment. Conclusion: Historically, differential diagnosis between amphicrine adenoma and adenocarcinoma of the middle ear has been very difficult. Carcinoid tumour is considered to be a more agressive form of amphicrine adenoma. Tumour progression is through loco regional invasion. Complete excision by surgical management with long term follow up is the treatment of choice.
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