Issue N# 3 - 2005
HEAD AND NECK SURGERY
Polymorphisms of the human OGG1 gene in laryngeal cancer: Implications in radiotherapy response and survival
Authors : E. Monteiro, G. Varzim, R. Silva, Barreira da Costa, C. Lopes (Porto)
Ref. : Rev Laryngol Otol Rhinol. 2005;126,3:135-140.
Article published in english
Downloadable PDF document english
The human OGG1 (hOGG1) gene encodes a DNA glycosylase involved in the excision repair of 8-hydroxy-2'-deoxyguanine (8-OH-dG) from oxidatively-damaged DNA. Ser326Cys polymorphism in the hOGG1 gene is involved in the repair of 8-hydroxyguanine in oxidatively damaged DNA, and appears to be related to susceptibility to certain smoking and alcohol-related orolaryngeal cancers. Objective: To analyse if hOGG1 Ser326Cys (exon 7: m6) polymorphism is associated with tumour localization, T, stage and histologic differentiation, and if radiotherapy results were influenced by this polymorphism. Material and method: Blood samples were obtained before treatment from seventy one patients with laryngeal cancer and screened by a PCR-RFLP method. Results: Although hOGG1 gene is important in DNA repair mechanisms, no significant association was observed between hOGG1 Ser326Cys (exon 7: m6) polymorphism, tumour characteristics and radiotherapy results. Conclusion: So the analysis of this polymorphism is not important for treatment decision in laryngeal cancer patients.
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