Issue N# 4 - 2011
Thyroid differenciated carcinoma in children. Study from Normandy
Authors : Blanchard D, Choussy O, Rame JP, Bequigon A, Dehesdin D, De Raucourt D, Bardet S, Babin E. (Caen, Rouen)
Ref. : Rev Laryngol Otol Rhinol. 2011;132,4:197-201.
Article published in french
Downloadable PDF document french
Objective: Definition of a strategy for the management of thyroid differenciated carcinoma in children. Design and setting: Retrospective cohort study from the Normandy area in France. Method: Analysis of the medical records of 13 children and adolescents (age >15 years), presenting with thyroid differenciated carcinoma in three Normandy French hospitals from 1994 to 2006, to determine the clinical features and treatment of the disease. Results: x of the patients were male and y were female, with a mean age at presentation of 11 years. Most frequently symptom was solitary nodes in the thyroid gland (69%). Most frequent histological type was papillary cancer (92%). Size of tumor was >4 cm in 23% of cases. Children had undergone surgery with total thyroidectomy, radio-iodine treatment and suppressive hormonotherapy. We observed 46% post surgery complications. All patients were alive and none developed a recurrence. Conclusion: Thyroid differenciated carcinoma in children and adolescents were more agressif with most frequently metastasis and recurrence than thyroid differenciated carcinoma of adults. Pronostic is goodwith 90% of survival at 20 years. We propose a coherent plan of treatment: 1° Thyroidectomy with cervical central lymph node dissection (group VI) completed bilateral selected head neck dissection compartments (groups IIa, III, IV) if macroscopic lymph node metastases in lateral cervical compartment. 2° Postoperative radioiodine is done in all tumor >T1N0 and completed with hormonotherapy.
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